Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG2-Val-Cit-PAB-PNP | 2112738-13-1 | 98.4% | 854.86 g/mol | C39H50N8O14 | 50 MG
Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable two-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs). It contains a val-cit dipeptide cleavable moiety, a p-aminobenzyl (PAB) self-immolative spacer, a para-nitrophenyl (PNP) leaving group, and a maleimide-amido PEG2 spacer for thiol conjugation.
- Cleavable val-cit dipeptide for enzyme-triggered payload release.
- PAB self-immolative spacer enables efficient drug release after cleavage.
- Maleimide-amido PEG2 spacer for thiol-selective conjugation to antibodies.
- High reported purity suitable for research-grade ADC synthesis.
- Available in small research sizes for development and testing.
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 100 mg
Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 100 mg
ABclonal Technology MICU2 Rabbit pAb
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 1-(4-(1,2,4,5-tetrazin-3-yl)phenyl)-3,19-dioxo-6,9,12,15-tetraoxa-22,23-... | 95.0% | 723.82 | C30H41N7O10S2 | 5 MG
Tetrazine-PEG4-SS-NHS is a cleavable PEG4 linker that features a tetrazine reactive group, a disulfide (SS) cleavable spacer, and an N-hydroxysuccinimide (NHS) ester for efficient bioconjugation and click chemistry applications.
- Cleavable disulfide spacer enables reductive release of payloads.
- Tetrazine group allows inverse electron demand Diels-Alder (iEDDA) click reactions.
- N-hydroxysuccinimide (NHS) ester provides amine-targeted conjugation chemistry.
- PEG4 spacer improves solubility and provides flexibility between conjugated partners.
- Typical purity 95.0% by NMR.
- Molecular weight 723.82, solid, purple to purplish red in color.
- Storage: powder at -20 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month).
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | MFCD11041099 | 98.8% | 207.27 | C9H21NO4 | 250 MG
m-PEG4-Amine is a polyethylene glycol (PEG) based bifunctional linker bearing a terminal primary amine. It is used as a short, flexible spacer in the synthesis of PROTACs and as a cleavable linker for antibody-drug conjugates, facilitating amine-based conjugation reactions.
- Provides a PEG4 spacer (~4 ethylene glycol units)
- Terminal primary amine for amide or carbamate conjugation
- High purity (98.8%) suitable for research use
- Molecular weight 207.27 g/mol
- Typically supplied as a solid; common pack size 250 MG
eMolecules Mal-PEG6-NHS ester | Broadpharm | 1599472-25-9 | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696
Mal-PEG6-NHS ester | Broadpharm | 1599472-25-9 | MFCD20926374 | 530.527 | C23H34N2O12 | 98.000 | O=C(CCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O | 250mg | 208572696
Medchemexpress LLC Bromoacetamido-PEG4-C2-Boc | 1807521-00-1 | 250 MG
Bromoacetamido-PEG4-C2-Boc is a laboratory chemical (CAS No. 1807521-00-1) primarily utilized in the manufacture of substances. This compound exhibits good stability when stored under recommended conditions and typically appears as a liquid. It possesses a molecular formula of C17H32BrNO7 and a molecular weight of 442.34.
- Suitable for laboratory research and substance manufacturing
- Stable under recommended storage conditions
- Appears as a liquid
- Molecular formula: C17H32BrNO7
- Molecular weight: 442.34
- Storage (pure form): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month
- Shipping at room temperature if less than 2 weeks
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204110.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.
- Provides a noncleavable 2-unit PEG spacer for conjugation
- NHS ester activated for efficient coupling to primary amines
- Aldehyde-phenyl functional group for orthogonal conjugation chemistry
- High purity suitable for research applications
- Available in multiple pack sizes and formats, including 100 MG
![Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-(PEG4-alkyne)oxy]phenyl ethyl ester | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204059.png-250.jpg)
Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-(PEG4-alkyne)oxy]phenyl ethyl ester | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 100 MG
PC Alkyne-PEG4-NHS ester is a cleavable PEG4 linker bearing an alkyne functional group and an N-hydroxysuccinimide (NHS) ester. It is used to attach payloads to amine-containing biomolecules via NHS chemistry and to enable azide-alkyne click reactions for bioconjugation and linker assembly.
- Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition.
- Features an NHS ester for efficient amine conjugation.
- PEG4 spacer provides solubility and flexibility for linker design.
- Typical applications include antibody-drug conjugate and PROTAC linker synthesis.
- Provided with analytical purity suitable for research use.
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 | C25H49N9O9 | 50 MG
NH2-C5-PEG4-N3-L-lysine-PEG3-N3 is a cleavable 7-unit PEG antibody-drug conjugate (ADC) linker containing an azide functional group, intended for research use in click chemistry conjugations. It facilitates attachment of payloads to biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC).
- Cleavable 7-unit PEG linker suitable for ADC synthesis.
- Azide functional group for CuAAC and SPAAC click reactions.
- High purity (≈99.4%).
- Water soluble: ≥100 mg/mL.
- Appearance: colorless to light yellow liquid.
- Recommended storage: pure form at -20°C.
- Packaged in 50 mg units.
eMolecules DNP-PEG3-DNP | 1365655-92-0 | MFCD22056318 | 1g
Broadpharm | DNP-PEG3-DNP | 1g | 550803886 | BP-20581 | 98.000 | 1365655-92-0 | MFCD22056318 | 524.443 | C20H24N6O11
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